Micropuncture Study of Renal Potassium Excretion in the Rat.
نویسندگان
چکیده
MALNIC, GERHARD, RUTH M. KLOSE, AND GERHARD GIEBISCH. Micropuncture study of renal potassium excretion in the rat: Am. J. Physiol. 206(4): 674-686. I g64.-Samples of proximal and distal tubular fluid were collected from rats maintained on a control, a low-K, or a high-K, low-Na diet. All animals received inulin-C 14. Plasma (P) and tubular fluid (TF) were analyzed for Na and K by dual-channel microflame photometry and assayed for radioactivity. Transtubular electrical potential differences were measured by means of glass microelectrodes. Mean TF/P ratios for potassium in the proximal tubule were slightly below unity in all groups of animals. A comparison of the relative increase in K and inulin-Cl4 along the distal tubule indicates: I) net movement of potassium into the tubular lumen in most control animals; 2) net movement of K into the tubular lumen of high-K, lowNa, sulfate-loaded animals, and in dichlorphenamide-treated animals on a control diet; and 3) the possibility of continued net reabsorption of potassium along the distal tubule and, particularly, the collecting duct in animals kept on a low-K diet. Distal tubular entry of potassium occurs down an electrochemical potential gradient.
منابع مشابه
Essays on Aps Classic Papers
This essay looks at the historical significance of six APS Classic Papers that are freely available on line: Malnic G, Klose RM, Giebisch G. Micropuncture study of renal potassium excretion in the rat. Am J Physiol 206: 674–686, 1964 (http://ajplegacy.physiology. org/cgi/reprint/206/4/674). Malnic G, Klose RM, Giebisch G. Micropuncture study of distal tubular potassium and sodium transport in r...
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ورودعنوان ژورنال:
- The American journal of physiology
دوره 206 شماره
صفحات -
تاریخ انتشار 1964